Precise, Expeditious & Dynamic
- Publication Planning
- Discussion Guides
- Executive Summaries
- Brand Plans
- Primary Manuscripts
- Review Articles
- Slide Decks
- Speaker Notes
- Global Value Dossiers
- Brain disorders
- HIV / AIDS»Immunology
The Patient Publication
Who we are: MedicalCommunications.co.uk is a company …. .
What we do: We provide clear, accurate, and engaging scientific and medical communications aimed at a wider audience.
What are our aims: Exceed expectations in the service we deliver; create a pathway to enlighten the public interest in science; and engage the public in dialogue where possible.
MedicalCommunications.co.uk is a UK based cooperative of medical communication professionals including: Medical Writers, Medical Editors, Strategists, Events Co-ordinators, Graphic Designers and Project Managers.
Projects delivered to your specifications.
MedicalCommunications.co.uk: Precise, Expeditious, Dynamic & In-Budget.
Submit a project to us click here.
PLEASE NOTE: We review and reply within 48 hours
Science and medical communications must be precise, distinctive and easy to read. We draw on the talents of experienced medical communications professionals who have an eye for detail and accuracy.
Medical Communications.co.uk – save time through clear and structured documents superseding the need for questions and explanations.
Project Types recently concluded:
· Primary manuscripts (preclinical and clinical)
· Review articles
· Letters to the editor
· Fully referenced outlines
· Slide decks with speaker notes
· Discussion guides
· Executive summaries
· Publication alerts
· Grant proposals
Therapy areas recently coordinated:
· Diabetes/ Metabolic
· Infectious disease
» Brain disorders
We are familiar with the fundamental background of brain disorders, and have a sound knowledge of the pathways involved and the unknowns/discrepancies that make neuropharmacology an exciting topic to explore.
Background: The brain is a complex organ with multiple neurotransmission pathways, which collectively, interact with each other to control our mental state. Neurotransmitters involved in signalling pathways such as, noradrenaline, serotonin, dopamine and acetylcholine are central to the design of therapies for the treatment of mental illnesses.
Noradrenaline – is an excitatory neurotransmitter involved in the control of functions such as attention. Noradrenergic neurons are present in the locus coeruleus and project to the cortex, hippocampus and thalamus.
Key player in the pathophysiology of anxiety, depression, post-traumatic stress disorder (PTSD).
Serotonin – It is mainly involved in mood, however has other functions such as regulation of sleep, pain perception, body temperature, blood pressure and hormonal activity is localised in nerve pathways emerging from the raphe nuclei.
Key player in the pathophysiology of anxiety, depression, panic disorder, PTSD and migraines
Dopamine – concentrated in very specific groups of neurons collectively called the basal ganglia. Dopaminergic neurons are widely distributed throughout the brain in three pathways: the nigrostriatal, mesocorticolimbic, and the tuberohypophyseal pathways.
Key player in the pathophysiology of Parkinson disease and schizophrenia.
Acetylcholine – is transmitted in the cholinergic pathways, which are concentrated in the brainstem. This neurotransmitter is important for cognitive function, mainly memory.
Key player in the pathophysiology of Alzheimers disease and sleep disorders.
The genetic background (gene mutations/polymorphisms) of an individual may influence their susceptibility, and predispose them to developing a mood or degenerative disorder. The genetic influences, like with many diseases (i.e. cancer), may explain why not all patients respond to a treatment, or if they do initially, they often experience a relapse.
Preclinical studies are fundamental in the study of brain disorders; they help to identify pathways involved in specific disorders, and explore the consequences of genetic mutations identified in man. Moreover, the effectiveness of current and novel therapies in development can be observed before extrapolated to man.
Other therapy areas which you maybe interested in reading about include Cardiovascular and Diabetes.
Cardiovascular refers to the heart and blood vessels (arteries and veins).
Cardiovascular disease is increasing on a global scale and each year kills more Americans than cancer.
There is an increasing emphasis being placed on preventing atherosclerosis by modifying risk factors, such as healthy eating, exercise and avoidance of smoking.
Other therapy areas here at MedicalCommunications.co.uk which you maybe interested in reading about include: Diabetes and HIV / AIDS.
» HIV / AIDS
HIV stands for: Human Immunodeficiency Virus
AIDS stands for: Acquired Immune Deficiency Syndrome
Two other therapy areas which you may be interested in reading about include: Immunology and Oncology.
When writing about cancer-related discoveries or novel treatments currently in development or implemented in experimental research, an understanding of the background and treatment concepts, including what dictates individual prognosis, is essential. Cancer is very much a heterogeneous disease that has an extensive classification system, and still today, new genes involved in the transformation of cells are being discovered. We are forever learning, from our genetic make-up, how cell processes are maintained and how they can go wrong. From this knowlege, research is at the forefront at discovering how we can manipulate these cell processes, to our advantage, in cancerous cells – indeed, this forms the basis of cancer research, and why it is an evergreen and rather complex field of research.
Most cancers are sporadic, and are caused by mutations in cells, transformation of which, compromise normal cell division. Causes of cancer range from environmental factors (exposure to carcinogens), acquired genetic abnormalities by DNA replication errors, or the inheritance of genetic abnormalities. It is possible to sub-classify people by their disease based on genetic markers, and can be used to predict the nature and intensity of treatment required, and indeed their prognosis.
The main culprits that acquire mutations are proto-oncogenes and tumor suppressor genes. Proto-oncogenes, that play a role in cell division and differentiation, may undergo modifications to become an oncogene. Oncogenes influence the signal transduction pathways and induce uncontrollable cell division. Whereas, tumor suppressor genes are involved in the normal cell cycle control and induce death by apoptosis upon detection of a replication error/damage. A defective gene coding for this protein, for example p53, causes errors in DNA replication or damage to the DNA by reactive oxygen species (ROS) to be left undetected, thus the cell is allowed to divide with these errors intact.
In some cases, people inherit genes that predispose them to developing cancer. For example,
Li-Fraumeni syndrome due to mutations of p53
Familial adenomatous polyposis (FAP), which is an inherited mutation of the APC gene that leads to early onset of colon carcinoma.
Hereditary nonpolyposis colorectal cancer (HNPCC; ‘Lynch syndrome’) that is caused by defects in DNA mismatch repair and can include familial cases of colon cancer, uterine cancer, gastric cancer, and ovarian cancer.
Retinoblastoma is due to a hereditary mutation in the retinoblastoma gene, and occurs in children.
BRCA1 and BRCA2, which normally play a role in protecting cells from DNA damage, are associated with an elevated risk of breast cancer and ovarian cancer.
The concept of cancer stem cells (‘CSCs’) has come to light of late, and may explain why people relapse and respond poorly to conventional treatment options. Indeed, conventional treatments only target the rapidly-growing cells that essentially constitute the tumor and not the “core” cells that instigate the tumor growth. Like normal stem cells, CSCs are able to reconstitute a new tumor with similar characteristics of the tumor of origin (i.e. express the same cell surface antigens). The cells share the same properties of normal stem cells in that they are slow cycling, capable of self-renewal and give rise to daughter cells that are self-renewing and pluripotent or transit amplifying and fully differentiated.
So far, CSCs have been identified and isolated in solid tumors such as breast cancer and ovarian cancer. Moreover, haematopoietic stem cells have been found in acute myeloid leukemia (AML).
Our experience across all therapy areas places us in a unique position to handle your medical communication needs.
Therapy areas recently coordinated:
· Diabetes/ Metabolic
· Infectious disease
Peripheral arterial disease
Hepatitis B and C
Renal cell carcinoma
Tumour lysis syndrome
Type I and II diabetes
Gastro-oesophageal reflux disease (GORD)
Numerous other therapy areas:
infectious diseases & vaccines
pain & inflammation
pharmacokinetics / pharmacodynamics
We deliver quality medical communication services to professional and public audiences. We strive on our ability to communicate medical information in an innovative and succinct way in order to meet and exceed the expectations of our clients.
Whether your medical communication service requirements are within the pharmaceutical, academic or public domain, we will work with you in a highly professional and enthusiastic manner to ensure you are completely satisfied with your product.
Medical Communications is more than a career to us, it is a passion. That passion is evident in the loyal and dedicated Medical Communication service we provide.
Precise Expeditious Dynamic
‘Medical writing is about communicating clinical and scientific data and information to a range of audiences in a wide variety of formats.’ EMWA
Uniquely we demonstrate a clear understanding of different therapy areas (Brain Disorders, Cancer Cardiovascular Disease & Diabetes) within the Therapy Areas section of the website.
We combine experience in communicating science and medicine, with expertise in editing, writing, and artwork production. Please contact us for more information on our medical communications services.